
Ligand-specific conformational changes of the μ-opioid receptor (μOR) translate into a broad range of intrinsic efficacies at the transducer level.


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Studies on the µ-opioid receptor using fluorescent labelling of intracellular residues and energy transfer experiments in the presence of different ligands with or without G-protein binding reveals conformational changes that correlate to ligand efficacy.

Ligand efficacy modulates conformational dynamics of the µ-opioid receptor - Nature

conformational-dynamics-of-the-μ-opioid-receptor-reveal-ligand-specific-efficacy-modulation


Conformational Dynamics of the μ-Opioid Receptor Reveal Ligand-Specific Efficacy Modulation
