
A phage-derived antibacterial enzyme can effectively target and eliminate biofilm-forming, pathogenic Enterococcus faecalis, a key driver of acute graft-versus-host disease after allogeneic hematopoietic cell transplantation.


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An analysis of the intestinal microbiome of people who have undergone allogenic haematopoietic cell transplantation shows that an enzyme derived from a bacteriophage has specific antibacterial activity against Enterococcus faecalis, and suppresses E. faecalis-associated graft-versus-host disease.

An enterococcal phage-derived enzyme suppresses graft-versus-host disease - Nature

phage-derived-enzyme-effectively-suppresses-graft-versus-host-disease-by-targeting-pathogenic-enterococcus-faecalis-biofilms


Phage-Derived Enzyme Effectively Suppresses Graft-Versus-Host Disease by Targeting Pathogenic Enterococcus faecalis Biofilms
