The content delves into the relationship between ovulatory menstrual cycles (MCs) and breast cancer (BC) risk, emphasizing the influence of progesterone (P4) on BC development. It highlights the importance of P4 in stimulating normal breast epithelium during MCs, leading to a higher risk of BC. The content discusses the impact of genetic variations, pathological conditions, and pharmaceutical interventions on MCs and BC risk. Furthermore, it explores the role of P4 in the proliferation of breast epithelium and the development of breast tumors over an extended period. The distinction between cause and stimulation in BC development is also addressed, focusing on reproductive factors, genetic mutations, and environmental influences. The content concludes by emphasizing the significant linear relationship between BC risk and the cumulative number of MCs experienced by women.
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by Herjan J. T.... lúc www.medscape.com 08-09-2023
http://www.medscape.com/viewarticle/994311Yêu cầu sâu hơn