Biogenic monoamines are crucial for various bodily functions and are stored in secretory vesicles by vesicular monoamine transporters (VMATs) for controlled release. VMATs use proton antiport to enrich monoamines and protect neurons from neurotoxicants. Therapeutic drugs target VMATs to treat neurodegenerative disorders, hypertension, and drug addiction. Cryo-electron microscopy structures of human VMAT1 reveal insights into its binding with different compounds, shedding light on the mechanism of vesicular monoamine transport.
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by Jin Ye,Huapi... lúc www.nature.com 03-18-2024
https://www.nature.com/articles/s41586-024-07290-7Yêu cầu sâu hơn