
초기 생활 경험이 드로솔파키닌 신호전달을 통해 성인기 사회적 행동의 가소성을 인코딩한다.


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Drosophila establishes social clusters in groups, yet the underlying principles remain poorly understood. Here we performed a systemic analysis of social network behavior (SNB) that quantifies individual social distance (SD) in a group over time. The SNB assessment in 175 inbred strains from the Drosophila Genetics Reference Panel revealed a tight association of short SD with long developmental time, low food intake, and hypoactivity. The developmental inferiority in short-SD individuals was compensated by their group culturing. By contrast, developmental isolation silenced the beneficial effects of social interactions in adults and blunted the plasticity of SNB under physiological challenges. Transcriptome analyses showed genetic diversity for SD traits, whereas social isolation reprogrammed select genetic pathways, regardless of SD phenotypes. In particular, social deprivation suppressed the expression of the neuropeptide Drosulfakinin ( Dsk ) in three pairs of adult brain neurons. Male-specific DSK signaling to Cholecystokinin-like receptor 17D1 mediated the SNB plasticity. In fact, transgenic manipulations of the DSK signaling were sufficient to imitate the state of social experience. Given the functional conservation of mammalian Dsk homologs, we propose that animals have evolved a dedicated neural mechanism to encode early-life experience and transform group properties adaptively.

### Competing Interest Statement

The authors have declared no competing interest.

Drosulfakinin signaling encodes early-life memory for adaptive social plasticity

자연-집단에서-드로설파키닌-신호전달이-적응적-사회적-가소성을-위한-초기-경험-기억을-인코딩한다


자연 집단에서 드로설파키닌 신호전달이 적응적 사회적 가소성을 위한 초기 경험 기억을 인코딩한다
