
Cholesterol acts as an orthosteric agonist, while the bitter tastant cmpd28.1 functions as a positive allosteric modulator with direct agonist activity at the bitter taste receptor TAS2R14.


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Cryo-electron microscopy structures of the type 2 taste receptor TAS2R14 in complex with Ggust and Gi1 identify cholesterol as an orthosteric agonist and the bitter tastant cmpd28.1 as a positive allosteric modulator and agonist.

Bitter taste receptor activation by cholesterol and an intracellular tastant - Nature

structural-insights-into-bitter-taste-receptor-tas2r14-activation-by-cholesterol-and-an-intracellular-bitter-tastant


Structural Insights into Bitter Taste Receptor TAS2R14 Activation by Cholesterol and an Intracellular Bitter Tastant
