Proteome Integral Solubility Alteration Reveals Antibiotic Mechanism of Action for Novel Nitro-Benzoxadiazole Compounds against Helicobacter pylori
A multi-omics approach integrating transcriptomics, proteomics, and Proteome Integral Solubility Alteration (PISA) assay was used to uncover the mechanism of action of novel nitro-benzoxadiazole compounds against the priority pathogen Helicobacter pylori.