
The piRNA pathway precisely regulates DNA methylation of young, active transposons during germline development in male mice through a two-factor authentication process involving the recruitment of SPIN1-SPOCD1 complex to young LINE1 promoters, followed by engagement of MIWI2 with the nascent transcript.


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In male mouse germline development, the precise DNA methylation of young, active transposons requires a two-step process in which SPIN1 and SPOCD1 mark young LINE1 elements before the piRNA pathway triggers DNA methylation.

Two-factor authentication underpins the precision of the piRNA pathway - Nature

precise-regulation-of-transposon-methylation-in-germline-development-requires-two-factor-authentication-in-the-pirna-pathway


Precise Regulation of Transposon Methylation in Germline Development Requires Two-Factor Authentication in the piRNA Pathway
