Structure of the Human Systemic RNAi Defective Transmembrane Protein 1 (hSIDT1) Reveals the Conformational Flexibility of its Lipid Binding Domain
The cryo-EM structure of the human systemic RNAi defective transmembrane protein 1 (hSIDT1) reveals a dimeric architecture with a flexible lipid binding domain (LBD) and a stable transmembrane domain (TMD) core, providing insights into the inherent conformational dynamics within the cholesterol uptake (ChUP) family of membrane proteins.