Enhancing DNA-Encoded Library Denoising through Multimodal Pretraining and Multi-Scale Compound Fusion

A novel Multimodal Pretraining DEL-Fusion (MPDF) model that enhances compound encoder capabilities through pretraining on diverse datasets and integrates compound information across atomic, submolecular, and molecular scales to enable comprehensive denoising of noisy DNA-encoded library (DEL) data.