Difluoromethylornithine Corrects Aberrant Polyamine Ratios in Snyder-Robinson Syndrome: Mechanism of Action and Therapeutic Potential
Difluoromethylornithine (DFMO) can effectively rebalance the aberrant spermidine-to-spermine ratio in Snyder-Robinson syndrome by reducing spermidine biosynthesis and enhancing spermine production through induction of S-adenosylmethionine decarboxylase.