
Conditional deletion of the Tert gene in the spermatogonial stem cell (SSC) population of mice impairs competitive clone formation, promotes stem cell differentiation, and reduces genome-wide open chromatin, independent of TERT's reverse transcriptase activity and the canonical telomerase complex.


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Studies in mice show that telomerase reverse transcriptase (TERT) has a role in enhancing stem cell competition that is independent of its reverse transcriptase activity, and&nbsp;promotes chromatin accessibility and activity of the MYC oncogene.

Clonal inactivation of TERT impairs stem cell competition - Nature

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Clonal Inactivation of Telomerase Reverse Transcriptase (TERT) Impairs Stem Cell Competition in Mice
