
Bacteria have evolved DNA glycosylase enzymes, such as Brig1, that can excise modified nucleobases from bacteriophage genomes, generating abasic sites and inhibiting viral replication as a defense mechanism against phage predation.


coremsg

A screen utilizing an environmental DNA library in Escherichia coli is used to identify Brig1, a previously unknown anti-phage defence system with homologues across distinct clades of bacteria.

DNA glycosylases provide antiviral defence in prokaryotes - Nature

discovery-of-a-dna-glycosylase-enzyme-that-provides-antiviral-defense-in-bacteria-against-bacteriophage-t4-infection


Discovery of a DNA Glycosylase Enzyme that Provides Antiviral Defense in Bacteria Against Bacteriophage T4 Infection
