The content discusses how the hallmark pathological features of Alzheimer's disease, namely amyloid-β plaques and tau tangles, are organized at the molecular level. Previous light microscopy studies have revealed the presence of these protein aggregates, but the precise arrangement of individual filaments within the plaques and tangles has remained unclear.
The authors used a technique called cryo-electron tomography to obtain high-resolution 3D images of brain tissue from Alzheimer's patients. This allowed them to visualize the intricate organization of amyloid-β and tau filaments that make up the plaques and tangles, respectively.
Key insights from the 3D microscopy data:
Overall, this study leverages cutting-edge imaging technology to shed unprecedented light on the molecular architecture of the hallmark Alzheimer's pathologies, which could inform the development of targeted therapies.
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by Sjors H. W. ... at www.nature.com 07-10-2024
https://www.nature.com/articles/d41586-024-02119-9Deeper Inquiries