Core Concepts
Detecting osteoporosis risk through a quick and inexpensive blood test.
Abstract
TOPLINE:
Researchers identified SNPs linked to osteoporosis risk from a drop of blood.
METHODOLOGY:
Blood samples were diluted and subjected to rapid thermolysis to extract DNA.
DNA was applied to an electrochemical device with gold electrodes for SNP detection.
Five SNPs associated with osteoporosis risk were detected and validated.
TAKEAWAY:
A portable device was developed to detect osteoporosis-associated SNPs from blood samples.
The entire assay was completed in 15 minutes at a low cost.
IN PRACTICE:
The platform has potential for automated SNP genotyping at the point of need.
SOURCE:
Study published in ACS Central Science by INTERFIBIO Research Group.
LIMITATIONS:
No study limitations reported.
DISCLOSURES:
Study received no commercial funding, and authors have no relevant financial relationships.
Stats
"The entire assay from the addition of the thermolyzed blood sample to the readout of the results was complete in just 15 minutes, with a cost per SNP, on a laboratory scale, including the cost of the electrode array and all reagents, of 0.3 euro (0.33 USD)."
Quotes
"The platform is completely generic and has immense potential for deployment at the point of need in an automated device for targeted SNP genotyping with the only required end-user intervention being sample addition." - Authors