
Jag2/Notch1 シグナル経路は、成体皮膚における皮脂腺分化の主要な調節因子であり、この経路の阻害は皮脂腺前駆細胞の増殖を促進する一方で分化を抑制する。


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The sebaceous gland (SG) is a vital appendage of the epidermis, and its normal homeostasis and function is crucial for effective maintenance of the skin barrier. Notch signaling is a well-known regulator of epidermal differentiation, and has also been shown to be involved in postnatal maintenance of SGs. However, the precise role of Notch signaling in regulating SG differentiation in the adult homeostatic skin remains unclear. While there is evidence to suggest that Notch1 is the primary Notch receptor involved in regulating the differentiation process, the ligand remains unknown. Using monoclonal therapeutic antibodies designed to specifically inhibit of each of the Notch ligands or receptors, we have identified the Jag2/Notch1 signaling axis as the primary regulator of sebocyte differentiation in homeostatic skin. Mature sebocytes are lost upon specific inhibition of the Jag2 ligand or Notch1 receptor, resulting in the accumulation of proliferative stem/progenitor cells in the SG. Most strikingly, this phenotype is reversible, as these stem/progenitor cells re-enter differentiation when the inhibition of Notch activity is lifted. Thus, Notch activity promotes correct sebocyte differentiation, and is required to restrict progenitor proliferation.

### Competing Interest Statement

The authors have declared no competing interest.

The Jag2/Notch1 signaling axis promotes sebaceous gland differentiation and controls progenitor proliferation

成体皮膚における-jag2-notch1-シグナル経路が皮脂腺分化を制御し-前駆細胞の増殖を制御する


成体皮膚における Jag2/Notch1 シグナル経路が皮脂腺分化を制御し、前駆細胞の増殖を制御する
