
細胞膜の高い水透過性により、マクロ分子凝縮による細胞内浸透圧緩衝は不可能である。


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[Watson et al . (2023][1], Macromolecular condensation buffers intracellular water potential, Nature 623: 842-852) have proposed that the reversible formation and disassembly of molecular condensates could act as the primary buffer of cytoplasmic osmolality in the face of changes in extracellular osmolality. In this communication, I show using well-established membrane biophysics, that the water permeability of plasma membranes is likely to overwhelm any cytoplasmic water buffers.

### Competing Interest Statement

The authors have declared no competing interest.

 [1]: #ref-27

Macromolecular condensation is unlikely to buffer intracellular osmolality

細胞内浸透圧を緩衝するマクロ分子凝縮は不可能である