
차가운 온도는 시상하부 뇌실주변핵(PVH)에서 신경 활성 의존적으로 지질 과산화와 지질 분해를 유도한다.


coremsg

Previous studies have been focused on lipid metabolism in peripheral tissues such as adipose tissues, while little or nothing is known about that in the brain. It is well recognized that cold acclimations enhance adipocyte functions, including white adipose tissue (WAT) lipid lipolysis and beiging, and brown adipose tissue (BAT) thermogenesis in mammals. However, it remains unclear whether and how the genes responsible for lipid metabolism in the brain are also under the control of cold acclimations. Here, we show that cold exposure predominantly increases the expressions of the genes encoding lipid lipolysis in the paraventricular nucleus of the hypothalamus (PVH). Mechanistically, we find that inactivation of neurons in the PVH blunts the cold-induced lipid peroxidation and lipolysis. Together, these findings indicate that lipid metabolism in the PVH is cold sensitive, potentially participating in cold regulations of energy metabolism.

### Competing Interest Statement

The authors have declared no competing interest.

Cold induces brain region-selective neuronal activity-dependent lipid metabolism

차가운-온도가-뇌-영역별-신경-활성-의존적-지질-대사를-유도한다


차가운 온도가 뇌 영역별 신경 활성 의존적 지질 대사를 유도한다
