
Catalytic enantioselective synthesis of chiral boron-containing nortricyclanes as isosteric replacements for meta-disubstituted aromatic rings in pharmaceuticals, offering improved biophysical properties and stereochemistry-dependent activity.


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A palladium-catalysed reaction converts hydrocarbon-derived precursors to chiral boron-containing nortricyclanes, and the shape of these nortricyclanes makes them plausible isosteres for meta disubstituted aromatic rings.

Catalytic asymmetric synthesis of meta benzene isosteres - Nature

catalytic-enantioselective-synthesis-of-meta-benzene-isosteres-for-improved-pharmaceutical-properties


Catalytic Enantioselective Synthesis of Meta Benzene Isosteres for Improved Pharmaceutical Properties
