
Subcellular protein localization can be modulated through molecular coupling to shuttle proteins, enabling the rewiring of the interactome to address disease-driving phenotypes.


coremsg

Targeted protein relocalization using shuttle proteins with potent ligands amenable to incorporation into targeted relocalization activating molecules could be used to regulate cellular physiology and correct disease states in neurodegenerative diseases, cancer and genetic disorders.

Targeted protein relocalization via protein transport coupling - Nature

harnessing-protein-transport-coupling-to-achieve-targeted-protein-relocalization-for-therapeutic-potential


Harnessing Protein Transport Coupling to Achieve Targeted Protein Relocalization for Therapeutic Potential
