DHODH Inhibition Enhances Immune Checkpoint Blockade Efficacy by Increasing Cancer Cell Antigen Presentation
Inhibition of dihydroorotate dehydrogenase (DHODH), a key enzyme in the de novo pyrimidine biosynthesis pathway, induces robust upregulation of antigen presentation pathway genes and increases tumor cell surface MHC-I expression, thereby enhancing the efficacy of immune checkpoint blockade in a preclinical melanoma model.