
感覚評価と行動選択という異なる神経プロセスは、選択性特化型のフィードバック接続を介して相互作用し、柔軟な意思決定の最適化に寄与する。


coremsg

Neural activity in the primate brain correlates with both sensory evaluation and action selection aspects of decision-making. However, the intricate interaction between these distinct neural processes and their impact on decision behaviors remains unexplored. Here, we examined the interplay of these decision processes in posterior parietal cortex (PPC) when monkeys performed a flexible decision task. We found that the PPC activity related to monkeys’ abstract decisions about visual stimuli was nonlinearly modulated by monkeys’ following saccade choices directing outside each neuron’s response field. Recurrent neural network modeling indicated that the feedback connections, matching the learned stimuli-response associations during the task, mediated such feedback modulation. Further analysis on network dynamics revealed that selectivity-specific feedback connectivity intensified the attractor basins of population activity underlying saccade choices, thereby increasing the consistency of flexible decisions. These results highlight an iterative computation between different decision processes, mediated primarily by precise feedback connectivity, contributing to the optimization of flexible decision-making.

### Competing Interest Statement

The authors have declared no competing interest.

Nonlinear feedback modulation contributes to the optimization of flexible decision-making

柔軟な意思決定中の異なる神経プロセスの相互作用を仲介する選択性特化型フィードバック接続