
IRE1 결핍은 간 손상과 콜라겐 침착을 감소시키며, 이는 P4HB 발현 감소와 관련이 있다. IRE1-P4HB 축은 콜라겐 생성과 분비를 조절하는 데 중요한 역할을 한다.


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Collagen is one the most abundant proteins and the main cargo of the secretory pathway, contributing to hepatic fibrosis and cirrhosis due to excessive deposition of extracellular matrix. Here we investigated the possible contribution of the unfolded protein response, the main adaptive pathway that monitors and adjusts the protein production capacity at the endoplasmic reticulum, to collagen biogenesis and liver disease. Genetic ablation of the ER stress sensor IRE1 reduced liver damage and diminished collagen deposition in models of liver fibrosis triggered by carbon tetrachloride (CCl4) administration or by high fat diet. Proteomic and transcriptomic profiling identified the prolyl 4-hydroxylase (P4HB, also known as PDIA1), which is known to be critical for collagen maturation, as a major IRE1-induced gene. Cell culture studies demonstrated that IRE1 deficiency results in collagen retention at the ER and altered secretion, a phenotype rescued by P4HB overexpression. Taken together, our results collectively establish a role of the IRE1/P4HB axis in the regulation of collagen production and its significance in the pathogenesis of various disease states.

### Competing Interest Statement

The authors have declared no competing interest.

The endoplasmic reticulum stress sensor IRE1 regulates collagen secretion through the enforcement of the proteostasis factor P4HB/PDIA1 contributing to liver damage and fibrosis

간섬망상체-스트레스-센서-ire1이-p4hb-pdia1-단백질-항상성-요인-강화를-통해-콜라겐-분비를-조절하여-간-손상-및-섬유화에-기여한다


간섬망상체 스트레스 센서 IRE1이 P4HB/PDIA1 단백질 항상성 요인 강화를 통해 콜라겐 분비를 조절하여 간 손상 및 섬유화에 기여한다
