
다양한 억제성 신경세포 클래스를 가진 피질 회로에서 SOM 신경세포 조절은 흥분성 신경세포의 활성과 회로 안정성을 동시에 증가시킬 수 있다.


coremsg

Synaptic inhibition is the mechanistic backbone of a suite of cortical functions, not the least of which are maintaining network stability and modulating neuronal gain. In cortical models with a single inhibitory neuron class, network stabilization and gain control work in opposition to one another – meaning high gain coincides with low stability and vice versa. It is now clear that cortical inhibition is diverse, with molecularly distinguished cell classes having distinct positions within the cortical circuit. We analyze circuit models with pyramidal neurons (E) as well as parvalbumin (PV) and somatostatin (SOM) expressing interneurons. We show when E – PV networks recurrently connect with SOM neurons then an SOM mediated modulation that leads to increased neuronal gain can also yield increased network stability. Our work exposes how the impact of an inhibition mediated modulation depends critically on how inhibition is recruited from within the circuit.

### Competing Interest Statement

The authors have declared no competing interest.

Untangling stability and gain modulation in cortical circuits with multiple interneuron classes

다양한-억제성-신경세포-클래스를-가진-피질-회로에서-안정성과-이득-조절-풀어내기


다양한 억제성 신경세포 클래스를 가진 피질 회로에서 안정성과 이득 조절 풀어내기
