
청각 피질 신경세포의 문맥 민감성과 스펙트로-시간적 튜닝은 깨어있는 생쥐에서 수일에 걸쳐 안정적으로 유지된다.


coremsg

The perceptual salience of a sound depends on the acoustic context in which it appears, and can vary on a timescale of milliseconds. At the level of single neurons in the auditory cortex, spectrotemporal tuning for particular sounds is shaped by a similarly fast and systematic nonlinear sensitivity to acoustic context. Does this neuronal context sensitivity “drift” over time in awake animals, or is it a stable feature of sound representation in the auditory cortex? We used chronically implanted tetrode arrays in awake mice to measure the electrophysiological responses of auditory cortical neurons to spectrotemporally complex, rapidly varying sounds across many days. For each neuron in each recording session, we applied the nonlinear-linear “context model” to estimate both a principal (spectrotemporal) receptive ﬁeld and a “contextual gain ﬁeld” describing the neuron’s nonlinear sensitivity to acoustic context. We then quantiﬁed the stability of these ﬁelds within and across days, using spike waveforms to match neurons recorded in multiple sessions. Contextual gain ﬁelds of auditory cortical neurons in awake mice were remarkably stable across many days of recording, and comparable in stability to principal receptive ﬁelds. Interestingly, there were small but signiﬁcant effects of changes in locomotion or pupil size on the ability of the context model to ﬁt temporal fluctuations in the neuronal response.

We conclude that both spectrotemporal tuning and nonlinear sensitivity to acoustic context are stable features of neuronal sound representation in the awake auditory cortex, which can be modulated by behavioral state.

### Competing Interest Statement

The authors have declared no competing interest.

Nonlinear sensitivity to acoustic context is a stable feature of neuronal responses to complex sounds in auditory cortex of awake mice

깨어있는-생쥐의-청각-피질에서-문맥-변조가-신경-코드의-안정적인-특징이다


깨어있는 생쥐의 청각 피질에서 문맥 변조가 신경 코드의 안정적인 특징이다
