
AIRE relies on Z-DNA and NFE2–MAF to select gene targets for thymic T cell tolerization by enhancing double-stranded break generation and promoter poising.


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Z-DNA anchors the AIRE-mediated transcriptional program by enhancing the generation of double-stranded breaks and promoter poising.

AIRE relies on Z-DNA to flag gene targets for thymic T cell tolerization - Nature

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AIRE's Mechanism: Z-DNA and T Cell Tolerization
