
Alveolar fibroblasts play multifaceted roles in maintaining normal alveolar homeostasis and orchestrating sequential responses to lung injury, including facilitating alveolar stem cell niches, regulating inflammatory and fibrotic fibroblast subsets, and eliciting intra-alveolar fibrosis.


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In mouse and human, lung-specialized alveolar fibroblasts adopt multiple molecular states that are induced by pro-inflammatory and fibrotic signals and have diverse protective roles against lung injury.

Alveolar fibroblast lineage orchestrates lung inflammation and fibrosis - Nature

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Alveolar Fibroblasts: Key Orchestrators of Lung Inflammation and Fibrosis
