Chaperone Complexes from the Endoplasmic Reticulum (ER) and the Cytosol Inhibit Wild-Type p53 by Activating the ER-to-Cytosol Signaling Pathway
Chaperone complexes from the ER and cytosol, specifically DNAJB12 and DNAJB14, regulate the reflux of ER proteins to the cytosol, which inhibits the activity of wild-type p53 in cancer cells.