
HSPA2는 마우스 배아의 2세포기에 비대칭적으로 발현되며, HSPA2 발현 감소는 내세포괴(ICM) 세포 운명 결정을 저해한다.


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The first cell-fate decision is the process by which cells of an embryo take on distinct lineage identities for the first time, thus representing the beginning of developmental patterning. Here, we demonstrate that the molecular chaperone heat shock protein A2 (HSPA2), a member of the 70 kDa heat shock protein (HSP70) family, is asymmetrically expressed in the late 2-cell stage of mouse embryos. The knockdown of Hspa2 in one of the two-cell blastomeres prevented its progeny predominantly toward the inner cell mass (ICM) fate, thus indicating that the differential distribution of HSPA2 in the blastomeres of two-cell embryos can influence the selection of embryonic cell lineages. In contrast, the overexpression of Hspa2 in one of the two-cell blastomeres did not induce blastomeres to differentiate towards the ICM fate. Furthermore, we demonstrated that HSPA2 forms a complex with CARM1 and activates ICM-specific gene expression. Collectively, our results identify HSPA2 as a critical regulator of the first cell-fate decision which specifies the ICM via the execution of commitment and differentiation phases.

### Competing Interest Statement

The authors have declared no competing interest.

The asymmetric expression of HSPA2 in blastomeres governs the first embryonic cell-fate decision

마우스-배아의-첫-번째-세포-운명-결정에-hspa2의-비대칭적-발현이-중요한-역할을-한다


마우스 배아의 첫 번째 세포 운명 결정에 HSPA2의 비대칭적 발현이 중요한 역할을 한다
