
Pneumococcal strains not included in the vaccine become more fit and resistant to penicillin over time, despite initial vaccine-driven decreases in antimicrobial resistance.


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Mathematical modelling of 15 years of data from South Africa reveals the spread and vaccine-driven changes in fitness and antimicrobial resistance of Streptococcus pneumoniae.

Geographical migration and fitness dynamics of Streptococcus pneumoniae - Nature

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Geographical Spread and Fitness Dynamics of Streptococcus pneumoniae Strains in South Africa


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Modeling the geographical migration and fitness changes of Streptococcus pneumoniae strains in response to pneumococcal conjugate vaccine implementation