The GTF2IRD1-transthyretin-ERK axis plays a critical role in the neurodevelopmental deficits observed in Williams Syndrome.
A subset of cerebellar nuclei neurons originates from an extrinsic germinal zone, potentially the mesencephalon, independently of the known cerebellar primordium germinal zones.
Mutations in the PTEN gene lead to selective impairments in the development and function of inhibitory GABAergic neurons, while excitatory cholinergic neurons remain unaffected. Dietary supplementation with the ketone body β-hydroxybutyrate during early development can rescue these GABAergic deficits by inducing the activity of the FOXO transcription factor.
The author explores the impact of Protocadherin10 deficiency in interneurons on socio-affective communication, particularly in relation to Autism Spectrum Disorder.
The author argues that the assembly of neuron- and radial glial cell-derived ECM molecules, specifically NCAN, TNC, and HA, plays a crucial role in promoting radial migration during cortical development.