
해마의 다차원적 기능적 조직화가 성인 전 생애에 걸친 기억 기능을 이해하는 데 중요하다.


coremsg

The hippocampus is a complex structure critically involved in numerous behavior-regulating systems. In young adults, multiple overlapping spatial modes along its longitudinal and transverse axes describe the organization of its functional integration with neocortex, extending the traditional framework emphasizing functional differences between sharply segregated hippocampal subregions. Yet, it remains unknown whether these modes (i.e., gradients) persist across the adult human lifespan, and relate to memory and molecular markers associated with brain function and cognition. In two independent samples, we demonstrate that the principal anteroposterior and second-order, mid-to-anterior/posterior hippocampal modes of neocortical functional connectivity, representing distinct dimensions of macroscale cortical organization, manifest across the adult lifespan. Specifically, individual differences in topography of the second-order gradient predicted episodic memory and mirrored dopamine D1 receptor distribution, capturing shared functional and molecular organization. Older age was associated with less distinct transitions along gradients (i.e., increased functional homogeneity). Importantly, a youth-like gradient profile predicted preserved episodic memory – emphasizing age-related gradient dedifferentiation as a marker of cognitive decline. Our results underscore a critical role of mapping multidimensional hippocampal organization in understanding the neural circuits that support memory across the adult lifespan.

### Competing Interest Statement

The authors have declared no competing interest.

Two long-axis dimensions of hippocampal-cortical integration support memory function across the adult lifespan

성인-전-생애에-걸친-해마의-피질-통합의-두-개의-장축-차원이-기억-기능을-지원한다


성인 전 생애에 걸친 해마의 피질 통합의 두 개의 장축 차원이 기억 기능을 지원한다
