
High-resolution structures of fetal and adult muscle nicotinic acetylcholine receptors provide insights into the structural principles underlying the switch from fetal to adult receptor isoforms during neuromuscular synapse maturation.


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Structures of fetal and adult muscle acetylcholine receptors reveal a developmental switch that alters channel biophysics and pharmacology to enable neuromuscular junction maturation, uncovering pathogenic mechanisms underlying congenital myasthenic syndromes.

Structural switch in acetylcholine receptors in developing muscle - Nature

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High-Resolution Structures Reveal Structural Switch in Acetylcholine Receptors During Neuromuscular Synapse Development
