
마우스 해마 치아 회백질(dentate gyrus)의 신경줄기세포 설립과 유지에 크로마틴 조절자 Kdm6b가 필수적이다.


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Neural stem cells (NSCs) in the mouse hippocampal dentate gyrus (DG) – a structure important to learning and memory – generate new neurons postnatally and throughout adult life. However, the regulators that enable this lifelong neurogenesis remain incompletely understood. Here we show that the chromatin regulator KDM6B is required for both the establishment and maintenance of NSCs in the mouse DG. Conditional deletion of Kdm6b in embryonic DG precursors results in an adult hippocampus that is essentially devoid of NSCs, and hippocampal-dependent behaviors are defective. Kdm6b -deletion causes precocious neuronal differentiation, and the NSC population fails to become established in the postnatal DG. Using single cell RNA sequencing (scRNA-seq), we observed that Kdm6b -deletion disrupts the transcriptomic signature of NSC maintenance. Furthermore, deleting Kdm6b in adult DG NSCs induces early neuronal differentiation, and the NSC population is not properly maintained. These data illustrate the critical role that Kdm6b plays in adult DG neurogenesis, which may help understand how mutations in this chromatin regulator result in cognitive disorders in human patients.

### Competing Interest Statement

The authors have declared no competing interest.

Chromatin regulator Kdm6b is required for the establishment and maintenance of neural stem cells in mouse hippocampus

성체-마우스-해마에서-신경줄기세포-유지에-필수적인-크로마틴-조절자-kdm6b


성체 마우스 해마에서 신경줄기세포 유지에 필수적인 크로마틴 조절자 Kdm6b
