SERBP1 Interacts with PARP1 and Participates in PARylation-Dependent Protein Complexes Regulating Splicing, Cell Division, and Ribosome Biogenesis
SERBP1, a multifunctional RNA-binding protein, interacts with PARP1 and participates in PARylation-dependent protein complexes involved in the regulation of splicing, cell division, and ribosome biogenesis.
Enhancing the Binding Affinity of SxIP Ligands to the EB1 Protein through Rational Peptide Design
The binding of SxIP-containing ligands to the EB1 protein involves a two-step "dock-and-lock" mechanism, where the initial docking through the SxIP motif provides specificity, and the subsequent folding of the EB1 C-terminus defines the full binding affinity.
리보솜 전사와 DNA 수리에 필수적인 Treacle의 상 분리
Treacle는 상 분리 능력을 통해 핵소체 섬유성 중심부의 형성과 유지, 리보솜 유전자 전사 및 전사체 처리 효율성 보장, 그리고 리보솜 유전자 손상에 대한 DNA 손상 반응 활성화에 중요한 역할을 한다.
Lactylation of NBS1 Protein Promotes DNA Repair and Chemotherapy Resistance in Cancer Cells
Lactate-driven lactylation of the NBS1 protein is essential for homologous recombination-mediated DNA repair, contributing to chemotherapy resistance in cancer cells.
포유동물의 중심체 근처 불연속적인 모티프를 표적으로 하여 이질염색질 개시
포유동물의 중심체 근처 이질염색질은 ZNF512와 ZNF512B 단백질에 의해 개시되며, 이들은 SUV39H 메틸트랜스퍼라제를 모집하여 H3K9 메틸화를 유도한다.
哺乳類の周期性ヘテロクロマチンの形成メカニズム：ZNF512とZNF512Bによる非連続的なDNA配列の認識
ZNF512とZNF512Bは、ヒストンH3のK9メチル化を触媒するSUV39H1/H2を直接リクルートすることで、周期性ヘテロクロマチンの形成を誘導する。これらの因子は、非連続的な3塩基配列を柔軟に認識することで、種間で保存された周期性ヘテロクロマチンの形成を可能にしている。
Zinc-Finger Proteins ZNF512 and ZNF512B Initiate Heterochromatin Formation at Pericentric Regions through Flexible DNA Binding
ZNF512 and ZNF512B zinc-finger proteins directly bind to pericentric DNA regions and recruit histone methyltransferases SUV39H1 and SUV39H2 to catalyze H3K9 methylation, thereby initiating heterochromatin formation.
High-Resolution Cryo-EM Structure of the Pseudomonas aeruginosa PAO1 Type IV Pilus Reveals Insights into Its Assembly and Architecture
The cryo-EM structure of the Pseudomonas aeruginosa PAO1 Type IV pilus provides detailed insights into the molecular architecture and assembly of this important bacterial surface appendage involved in adhesion, motility, and biofilm formation.
ISエレメントの橋渡しRNAによる組換えメカニズムの構造解明
ISエレメントの組換えリコンビナーゼは、標的DNAと供与DNAの結合を制御する橋渡しRNAを利用して、プログラム可能な組換え反応を行う。
トランスポゼースの活性化を担う専用のAAA+ ATPaseの分子基盤
AAA+ ATPaseレギュレーターが、標的DNAの変形と転移酵素の招集・活性化を通じて、トランスポゾンの機能を促進する。
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