SE(3)-Invariant Generative Models for Designable and Novel Protein Backbone Generation

FOLDFLOW, a family of simulation-free generative models based on the flow-matching paradigm over the group SE(3), enables accurate and efficient modeling of protein backbones. The FOLDFLOW models offer several key advantages over previous approaches, including stability, faster training, and the ability to map any invariant source distribution to any invariant target distribution over SE(3).