Inhaled Spectinamide 1599 Combined with Bedaquiline and Pretomanid Shows Equivalent Efficacy to Linezolid-Containing Regimen for Tuberculosis Treatment while Avoiding Linezolid-Associated Adverse Effects
Inhaled spectinamide 1599 combined with bedaquiline and pretomanid (BPaS regimen) has similar efficacy to the BPaL regimen (bedaquiline, pretomanid, linezolid) in murine tuberculosis models, but avoids the linezolid-associated adverse effects.