
은퇴 후 맞이하는 삶은 예상치 못한 기쁨과 슬픔, 그리고 노화와 죽음이라는 현실을 마주하게 하지만, 행복을 추구할 권리는 누구에게나 주어진다.


coremsg

Money, mediocrity, the entropy of aging, myths of meaning, and yes … the inescapable Reaper.

Three Years Retired: Secrets of Happiness, Reality, and the Inevitable

3년간의-은퇴-생활-행복-현실-그리고-피할-수-없는-것들에-대한-단상


3년간의 은퇴 생활: 행복, 현실 그리고 피할 수 없는 것들에 대한 단상


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圖表顯示了醫生們對病人、其他醫生和同事互動中出現的一些問題的回答，包括對老年醫生進行認知測試、與病人約會以及向病人解釋使用大麻的風險等問題。


Cognitive tests for doctors and dating patients are among scenarios in an infographic on issues in physicians' interactions with one another and patients.

Infographic: Cognitive Tests for Older Docs?

醫生對於達到一定年齡後需要接受認知測驗的想法有什麼看法-


醫生對於達到一定年齡後需要接受認知測驗的想法有什麼看法？



Medscape 설문조사에 따르면, 의사들은 특정 연령에 도달한 의사에게 필수적인 인지 검사를 요구하는 것과 같은 문제에 대해 다양한 의견을 가지고 있습니다.


고령-의사-대상-인지-검사에-대한-의사들의-생각-medscape-설문조사-결과


고령 의사 대상 인지 검사에 대한 의사들의 생각: Medscape 설문조사 결과



A recent Medscape survey reveals insights into doctors' opinions on timely issues like mandatory cognitive testing for older physicians, ethical dilemmas like dating patients, and the need for patient education about marijuana use in light of its increasing accessibility.


doctors-opinions-on-cognitive-tests-dating-patients-and-marijuana-use-insights-from-a-medscape-survey


Doctors' Opinions on Cognitive Tests, Dating Patients, and Marijuana Use: Insights from a Medscape Survey



식이 제한이 수명 연장에 효과적인 것으로 알려져 있지만, 최근 연구에 따르면 유전적 요인이 수명에 더 큰 영향을 미치는 것으로 밝혀졌습니다.


Huge study of mice reveals effects of dietary restriction on lifespan.

Dietary restriction can extend lifespan — but genetics matters more

유전적-요인이-더-중요하지만-식이-제한은-수명을-연장할-수-있다


유전적 요인이 더 중요하지만, 식이 제한은 수명을 연장할 수 있다



食事制限はマウスの寿命延長に効果があると期待されているが、Di Francescoらの研究によると、遺伝的要因の方がより大きな影響力を持つ。


遺伝子が寿命に与える影響は-食事制限よりも大きい


遺伝子が寿命に与える影響は、食事制限よりも大きい



노화에 따른 혈액 내 특정 인자 변화가 말초 세포의 생체 시계 리듬을 변화시키고, 이는 산화적 인산화 및 콜레스테롤 생합성과 관련된 유전자 발현에 영향을 미쳐 건강과 질병에 영향을 줄 수 있다.


Aging is associated with a number of physiologic changes including perturbed circadian rhythms; however, mechanisms by which rhythms are altered remain unknown. To test the idea that circulating factors mediate age-dependent changes in peripheral rhythms, we compared the ability of human serum from young and old individuals to synchronize circadian rhythms in culture. We collected blood from apparently healthy young (age 25-30) and old (age 70-76) individuals at 14:00 and used the serum to synchronize cultured fibroblasts. We found that young and old sera are equally competent at initiating robust ∼24h oscillations of a luciferase reporter driven by clock gene promoter. However, cyclic gene expression is affected, such that young and old sera promote cycling of different sets of genes. Genes that lose rhythmicity with old serum entrainment are associated with oxidative phosphorylation and Alzheimer’s Disease as identified by STRING and IPA analyses. Conversely, the expression of cycling genes associated with cholesterol biosynthesis increased in the cells entrained with old serum. Genes involved in the cell cycle and transcription/translation remain rhythmic in both conditions. We did not observe a global difference in the distribution of phase between groups, but found that peak expression of several clock-controlled genes ( PER3, NR1D1, NR1D2, CRY1, CRY2, and TEF ) lagged in the cells synchronized ex vivo with old serum. Taken together, these findings demonstrate that age-dependent blood-borne factors affect circadian rhythms in peripheral cells and have the potential to impact health and disease via maintaining or disrupting rhythms respectively.

### Competing Interest Statement

The authors have declared no competing interest.

Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms

인간-혈액-매개-인자가-연령-관련-분자-생체-시계-리듬-변화에-미치는-역할에-대한-증거


인간 혈액 매개 인자가 연령 관련 분자 생체 시계 리듬 변화에 미치는 역할에 대한 증거



加齢に伴う血中因子の変化は、末梢細胞の概日リズムに影響を与え、リズムの維持または破壊を通じて、それぞれ健康と病気に影響を与える可能性がある。


ヒト血中因子による加齢に伴う分子時計リズム変化の媒介における役割の証拠


인간의 수명은 한계에 도달했으며, 획기적인 의학 발전에도 불구하고 1997년 이후 최장 수명 기록은 갱신되지 않았다.


Lifespan advances are near biological limits, the thinking goes. So we should focus instead on healthspan.

Humans Can’t Live Much Longer, New Evidence Suggests

인간-수명-연장의-한계-새로운-연구-결과


인간 수명 연장의 한계: 새로운 연구 결과



衛生状態の改善や医療の進歩により、20世紀初頭から人間の平均寿命は劇的に延びましたが、ここ数十年の進歩は鈍化しており、現在の平均寿命は限界に近づいている可能性があります。


人間の寿命にはこれ以上の延長は望めない-新たな研究結果が示唆


人間の寿命にはこれ以上の延長は望めない：新たな研究結果が示唆
