
PP2A-B56リン酸化酵素は、Mid1タンパク質のレベルを調整することで、分裂酵母の適切な細胞分裂を促進する。


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Protein phosphorylation regulates many steps in the cell division process including cytokinesis. In the fission yeast S. pombe , the anillin-like protein Mid1 sets the cell division plane and is regulated by phosphorylation. Multiple protein kinases act on Mid1, but no protein phosphatases have been shown to regulate Mid1. Here, we discovered that the conserved protein phosphatase PP2A-B56 is required for proper cytokinesis by promoting Mid1 protein levels. We find that par1 Δ cells lacking the primary B56 subunit divide asymmetrically due to the assembly of misplaced cytokinetic rings that slide toward cell tips. These par1 Δ mutants have reduced whole-cell levels of Mid1 protein, leading to reduced Mid1 at the cytokinetic ring. Restoring proper Mid1 expression suppresses par1 Δ cytokinesis defects. This work identifies a new PP2A-B56 pathway regulating cytokinesis through Mid1, with implications for control of cytokinesis in other organisms.

### Competing Interest Statement

The authors have declared no competing interest.

PP2A-B56 regulates Mid1 protein levels for proper cytokinesis in fission yeast

pp2a-b56リン酸化酵素がmid1タンパク質レベルを調整することで-分裂酵母の適切な細胞分裂を制御する


PP2A-B56リン酸化酵素がMid1タンパク質レベルを調整することで、分裂酵母の適切な細胞分裂を制御する
