
Engineered phage-derived particles can efficiently deliver base editors to modify target genes in gut bacteria colonizing the mouse intestine, enabling investigation of bacterial gene function and potential microbiome-targeted therapies.


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Edited bacteria were stably maintained in mouse gut for at least 42 days following the delivery of a base editor using an engineered phage-derived particle to&nbsp;modify Escherichia coli colonizing the gut.

In situ targeted base editing of bacteria in the mouse gut - Nature

targeted-in-situ-base-editing-of-gut-bacteria-in-mice-using-engineered-phage-particles


Targeted In Situ Base Editing of Gut Bacteria in Mice Using Engineered Phage Particles
