Cyclin-Dependent Kinase Phosphorylation of Polynucleotide Kinase Phosphatase Promotes Okazaki Fragment Processing and Genome Stability During DNA Replication
Phosphorylation of PNKP at threonine 118 by CDKs is essential for its recruitment to single-strand DNA gaps between Okazaki fragments, allowing PNKP to process the ends and promote their ligation, thereby maintaining genome stability during DNA replication.