단일-이미지-초해상도-복원을-위한-전역-지역-정보-시너지-기반-접근법

robust-non-overshooting-sliding-mode-control-for-uav-trajectory-tracking

uavの制御のための非オーバーシュート型スライディングモード

무인항공기-제어를-위한-비과도-슬라이딩-모드

keystroke-biometrics-verification-system-with-dual-branch-architecture-attention-mechanisms-and-set2set-loss

大規模ユーザーを対象とした高精度なキーストロークバイオメトリクスシステム-type2branchモデル

대량의-사용자를-위한-주의-집중-메커니즘과-set2set-손실-함수를-사용한-이중-분기-아키텍처-기반-키스트로크-생체-인식

learning-object-states-from-actions-using-large-language-models


MMP-9は、BDNF依存性のシグナル伝達を介して、構造的シナプス可塑性を制御する。


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Synaptic plasticity underlies learning and memory processes as well as contributes, in its aberrant form, to neuropsychiatric disorders. One of its major forms is structural long-term potentiation (sLTP), an activity-dependent growth of dendritic spines that harbor excitatory synapses. The process depends on the release of brain-derived neurotrophic factor (BDNF), and activation of its receptor, TrkB. Matrix metalloproteinase-9 (MMP-9), an extracellular protease is essential for many forms of neuronal plasticity engaged in physiological as well as pathological processes. Here, we utilized two-photon microscopy and two-photon glutamate uncaging to demonstrate that MMP-9 activity is essential for sLTP and is rapidly (∼seconds) released from dendritic spines in response to synaptic stimulation. Moreover, we show that either chemical or genetic inhibition of MMP-9 impairs TrkB activation, as measured by fluorescence lifetime imaging microscopy of FRET sensor. Furthermore, we provide evidence for a cell-free cleavage of proBDNF into mature BDNF by MMP-9. Our findings point to the autocrine mechanism of action of MMP-9 through BDNF maturation and TrkB activation during sLTP.

### Competing Interest Statement

R.Y. is a founder of Florida Lifetime Imaging LLC.

BDNF signaling requires Matrix Metalloproteinase-9 during structural synaptic plasticity

mmp-9による構造的シナプス可塑性の制御-bdnfシグナル依存性


MMP-9による構造的シナプス可塑性の制御 - BDNFシグナル依存性


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シナプス可塑性におけるMMP-9の役割