
大脳皮質からの広範な入力を統合し、局所的な計算を行った後に再分配することで、大脳皮質の情報ストリームを結合するのが大脳基底核の役割である。


coremsg

The claustrum is thought to be one of the most highly interconnected forebrain structures but its organizing principles have yet to be fully explored at the level of single neurons. Here, we investigated the identity, connectivity, and activity of identified claustrum neurons to understand how the structure’s unique convergence of input and divergence of output support binding information streams. We found that neurons in the claustrum communicate with each other across efferent projection-defined modules which were differentially innervated by sensory and frontal cortical areas. Individual claustrum neurons were responsive to inputs from more than one cortical region in a cell-type and projection-specific manner, particularly between areas of frontal cortex. In vivo imaging of claustrum axons revealed responses to both unimodal and multimodal sensory stimuli. Finally, chronic claustrum silencing specifically reduced animals’ sensitivity to multimodal stimuli. These findings support the view that the claustrum is a fundamentally integrative structure, consolidating information from around the cortex and redistributing it following local computations.

### Competing Interest Statement

The authors have declared no competing interest.

Single neurons and networks in the claustrum integrate input from widespread cortical sources

単一ニューロンと神経ネットワークが広範な大脳皮質からの入力を統合する