kollaboratives-graph-kontraststlernen-ohne-handgefertigte-graph-datenerweiterungen

플라나-시스템의-이벤트-트리거-제어-하에서-이벤트-간-시간의-점근적-행동-분석

多タスク学習とロバスト統計を用いたバンディット問題の解決

equilibrium-dynamics-and-sustainability-of-decentralized-pricing-for-dissipative-assets-in-honest-pinfi-systems

asymptotisches-verhalten-der-zeitabstände-zwischen-ereignissen-in-planaren-systemen-unter-ereignisgesteuerter-regelung

職場におけるパッシブセンシングの包括的な調査

다중-과제-학습-및-강건-통계를-활용한-밴딧-학습

連邦学習における通信効率的なクライアントグラジエントの活用


ERKシグナル伝達は、未分化状態の維持と分化状態への移行の両方を制御する。ERKの活性化は未分化状態の転写因子ネットワークを解体し、一方で主要な多能性因子Oct4の発現を維持することで、幹細胞の分化状態への移行を促進する。


coremsg

Naïve epiblast cells in the embryo and pluripotent stem cells in vitro undergo developmental progression to a formative state competent for lineage specification. During this transition, transcription factors and chromatin are rewired to encode new functional features. Here, we examine the role of mitogen-activated protein kinase (ERK1/2) signalling in pluripotent state transition. We show that a primary consequence of ERK activation in mouse embryonic stem cells is elimination of Nanog, precipitating breakdown of the naïve state gene regulatory network. Cell variability in pERK dynamics results in metachronous down-regulation of Nanog and naïve state exit. Knockdown of Nanog allows exit without ERK activation. However, transition to formative pluripotency does not proceed and cells collapse to an indeterminate identity. This failure is attributable to loss of expression of the central pluripotency factor Oct4. Thus, during formative transition ERK signalling both dismantles the naïve state and preserves pluripotency. These results illustrate that a single signalling pathway can both drive exit from a developmental state and safeguard progression to the successor state.

### Competing Interest Statement

The authors have declared no competing interest.

ERK signalling orchestrates metachronous transition from naïve to formative pluripotency

幹細胞の未分化状態から分化状態への移行におけるerkシグナル伝達の役割


幹細胞の未分化状態から分化状態への移行におけるERKシグナル伝達の役割


title_rewrite

幹細胞の未分化状態から分化状態への移行