
意識レベルの変化に伴い、脳活動の流体力学的特性と応答性が変化する。


coremsg

Signatures of consciousness are found in spectral and temporal properties of neuronal activity. Among these, spatiotemporal complexity after a perturbation has recently emerged as a robust metric to infer levels of consciousness. Perturbation paradigms remain, however, difficult to perform routinely. To discover alternative paradigms and metrics we systematically explore brain stimulation and resting-state activity in a digital brain twin model. We find that perturbational complexity only occurs when the brain model operates within a specific dynamical regime, in which spontaneous activity produces a large degree of functional network reorganizations referred to as being fluid. The regime of high brain fluidity is characterized by a small battery of metrics drawn from dynamical systems theory and predicts the impact of consciousness altering drugs (Xenon, Propofol and Ketamine). We validate the predictions in a cohort of 15 subjects at various stages of consciousness and demonstrate their agreement with previously reported perturbational complexity, but in a more accessible paradigm. Beyond the facilitation in clinical use, the metrics highlights complexity properties of brain dynamics in support of emergence of consciousness.

### Competing Interest Statement

The authors have declared no competing interest.

Spatiotemporal brain complexity quantifies consciousness outside of perturbation paradigms

大規模脳活動の流体力学的特徴と意識との関連性