ランダムトレーニングを用いたフリードリヒス系のための局所縮小空間の構築

무작위-학습을-통한-friedrichs-시스템의-국소-축소-공간-구축

continuously-adaptive-deep-learning-approach-for-dimensionality-reduction-and-model-order-reduction-of-parametric-pdes

パラメータ依存偏微分方程式のための適応的データ駆動型次元削減手法-深層直交分解

매개변수-의존-편미분-방정식의-연속-적응형-데이터-기반-모델-차수-감소-기법-deep-orthogonal-decomposition

establishing-a-standardized-process-for-integrating-radiology-images-with-electronic-health-records-at-the-national-level

全国レベルでの放射線画像管理の標準化プロセスに向けて

국가-차원의-표준화된-방사선-영상-관리-프로세스-구축을-향하여


다양한 공간 전사체 프로파일링 기술을 비교 분석하여 각 기술의 민감도와 특이도를 평가하고, 이를 통해 기술 간 성능 차이를 이해하고자 한다.


coremsg

The burgeoning interest in in situ multiplexed gene expression profiling technologies has opened new avenues for understanding cellular behavior and interactions. In this study, we present a comparative benchmark analysis of six in situ gene expression profiling methods, including both commercially available and academically developed methods, using publicly accessible mouse brain datasets. We find that standard sensitivity metrics, such as the number of unique molecules detected per cell, are not directly comparable across datasets due to substantial differences in the incidence of off-target molecular artifacts impacting specificity. To address these challenges, we explored various potential sources of molecular artifacts, developed novel metrics to control for them, and utilized these metrics to evaluate and compare different in situ technologies. Finally, we demonstrate how molecular false positives can seriously confound spatially-aware differential expression analysis, requiring caution in the interpretation of downstream results. Our analysis provides guidance for the selection, processing, and interpretation of in situ spatial technologies.

### Competing Interest Statement

A.H. was employed by 10x Genomics from July 2020 to September 2021 and owns stock in the company. In the past 3 years, R.S. has received compensation from Bristol-Myers Squibb, ImmunAI, Resolve Biosciences, Nanostring, 10x Genomics, Neptune Bio, and the NYC Pandemic Response Lab. R.S. is a co-founder and equity holder of Neptune Bio.

Comparative analysis of multiplexed in situ gene expression profiling technologies

다양한-공간-전사체-프로파일링-기술의-비교-분석


다양한 공간 전사체 프로파일링 기술의 비교 분석


title_rewrite

공간 전사체 프로파일링 기술 비교