ai-for-biomedicine-large-language-models-exploration

safe-and-stable-formation-control-with-adaptive-control-and-barrier-functions

学校割り当てのための近似アルゴリズム-グループ公平性と多目的最適化

efficient-animal-species-classification-model-in-hong-kong-using-active-learning

semantic-gaussians-open-vocabulary-scene-understanding-with-3d-gaussian-splatting

ac4-algebraic-computation-checker-for-circuit-constraints-in-zero-knowledge-proofs

確率システムにおける不確実性伝播-混合モデルと誤差定量を用いた手法

conservative-surrogate-models-for-optimization-with-the-active-subspace-method


노화에 따라 미세아교세포는 중간 단계의 상태를 거치면서 염증 활성화 상태로 진행되며, 이는 해마 의존적 인지 기능 저하를 유발한다.


coremsg

During aging, microglia – the resident macrophages of the brain – exhibit dystrophic phenotypes and contribute to age-related neuroinflammation. While numerous hallmarks of age-related microglia dystrophy have been elucidated, the progression from homeostasis to dysfunction during the aging process remains unresolved. To bridge this gap in knowledge, we undertook complementary cellular and molecular analyses of microglia in the mouse hippocampus across the adult lifespan and in the experimental aging model of heterochronic parabiosis. Single-cell RNA-Seq and pseudotime analysis revealed age-related transcriptional heterogeneity in hippocampal microglia and identified intermediate states of microglial aging that also emerge following heterochronic parabiosis. We tested the functionality of intermediate stress response states via TGFβ1 and translational states using pharmacological approaches in vitro to reveal their modulation of the progression to an inflammatory state. Furthermore, we utilized single-cell RNA-Seq in conjunction with an in vivo adult microglia-specific Tgfb1 conditional genetic knockout mouse model, to demonstrate that microglia advancement through intermediate aging states drives inflammatory activation and associated hippocampal-dependent cognitive decline.

### Competing Interest Statement

The authors have declared no competing interest.

Microglia aging in the hippocampus advances through intermediate states that drive inflammatory activation and cognitive decline

노화에-따른-해마-내-미세아교세포의-염증-활성화와-인지-기능-저하를-유발하는-중간-단계-상태


노화에 따른 해마 내 미세아교세포의 염증 활성화와 인지 기능 저하를 유발하는 중간 단계 상태


title_rewrite

노화에 따른 미세아교세포의 염증 활성화 과정