
뇌 구조 연결망이 풍부한 패턴의 기능적 동기화를 형성하여 복잡한 인지 및 행동 능력을 지원한다. 그러나 구조-기능 결합의 발달과 이것이 인지 기능 및 전사체 구조와 어떤 관계가 있는지는 명확하지 않다.


coremsg

Brain structural circuitry shapes a richly patterned functional synchronization, supporting for complex cognitive and behavioural abilities. However, how coupling of structural connectome (SC) and functional connectome (FC) develops and its relationships with cognitive functions and transcriptomic architecture remain unclear. We used multimodal magnetic resonance imaging data from 439 participants aged 5.7 to 21.9 years to predict functional connectivity by incorporating intracortical and extracortical structural connectivity, characterizing SC-FC coupling. Our findings revealed that SC-FC coupling was strongest in the visual and somatomotor networks, consistent with evolutionary expansion, myelin content, and functional principal gradient. As development progressed, SC-FC coupling exhibited heterogeneous alterations dominated by an increase in cortical regions, broadly distributed across the somatomotor, frontoparietal, dorsal attention, and default mode networks. Moreover, we discovered that SC-FC coupling significantly predicted individual variability in general intelligence, mainly influencing frontoparietal and default mode networks. Finally, our results demonstrated that the heterogeneous development of SC-FC coupling is positively associated with genes in oligodendrocyte-related pathways and negatively associated with astrocyte-related genes. This study offers insight into the maturational principles of SC-FC coupling in typical development.

### Competing Interest Statement

The authors have declared no competing interest.

Spatial and temporal pattern of structure-function coupling of human brain connectome with development

뇌-연결망의-구조-기능-결합의-공간-및-시간적-패턴-발달에-따른-변화


뇌 연결망의 구조-기능 결합의 공간 및 시간적 패턴: 발달에 따른 변화
