
claustrum은 다양한 피질 영역으로부터의 입력을 통합하여 정보를 처리하고 재분배하는 핵심적인 역할을 수행한다.


coremsg

The claustrum is thought to be one of the most highly interconnected forebrain structures but its organizing principles have yet to be fully explored at the level of single neurons. Here, we investigated the identity, connectivity, and activity of identified claustrum neurons to understand how the structure’s unique convergence of input and divergence of output support binding information streams. We found that neurons in the claustrum communicate with each other across efferent projection-defined modules which were differentially innervated by sensory and frontal cortical areas. Individual claustrum neurons were responsive to inputs from more than one cortical region in a cell-type and projection-specific manner, particularly between areas of frontal cortex. In vivo imaging of claustrum axons revealed responses to both unimodal and multimodal sensory stimuli. Finally, chronic claustrum silencing specifically reduced animals’ sensitivity to multimodal stimuli. These findings support the view that the claustrum is a fundamentally integrative structure, consolidating information from around the cortex and redistributing it following local computations.

### Competing Interest Statement

The authors have declared no competing interest.

Single neurons and networks in the claustrum integrate input from widespread cortical sources

단일-뉴런과-신경망이-광범위한-피질-입력을-통합하는-claustrum의-역할


단일 뉴런과 신경망이 광범위한 피질 입력을 통합하는 claustrum의 역할
