ウェハーススケールでの追跡可能なエージェントベースの進化モデル

대규모-웨이퍼-스케일-에이전트-기반-진화-모델의-추적-가능성

vocabulary-free-image-classification-and-semantic-segmentation-leveraging-vision-language-models-and-external-databases-for-unconstrained-semantic-categorization

画像分類とセマンティックセグメンテーションにおける語彙フリーアプローチ

언어-의존적이지-않은-이미지-분류-및-의미-분할

a-modular-framework-for-open-set-object-detection-and-discovery

オープンセット物体検出と発見のための簡単でモジュール式のフレームワーク

개방형-객체-탐지-및-발견을-위한-간단하고-모듈식-프레임워크-osr-vit


Dickkopf-2(DKK2)는 대장암 전이 과정에서 Paneth 세포 특성을 가진 암세포 생성에 필수적이다.


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Metastasis is the leading cause of cancer-related mortality. Paneth cells provide stem cell niche factors in homeostatic conditions, but the underlying mechanisms of cancer stem cell niche development are unclear. Here we report that Dickkopf-2 (DKK2) is essential for the generation of cancer cells with Paneth cell properties during colon cancer metastasis. Splenic injection of Dkk2 -knockout (KO) cancer organoids into C57BL/6 mice resulted in a significant reduction of liver metastases. Transcriptome analysis showed reduction of Paneth cell markers such as lysozymes in KO organoids. Single cell RNA sequencing analyses of murine metastasized colon cancer cells and patient samples identified the presence of lysozyme positive cells with Paneth cell properties including enhanced glycolysis. Further analyses of transcriptome and chromatin accessibility suggested Hepatocyte nuclear factor 4-alpha (HNF4A) as a downstream target of DKK2. Chromatin immunoprecipitation followed by sequencing analysis revealed that HNF4A binds to the promoter region of Sox9 , a well-known transcription factor for Paneth cell differentiation. In the liver metastatic foci, DKK2 knockout rescued HNF4A protein levels followed by reduction of lysozyme positive cancer cells. Taken together, DKK2-mediated reduction of HNF4A protein promotes the generation of lysozyme positive cancer cells with Paneth cell properties in the metastasized colon cancers.

### Competing Interest Statement

The authors have declared no competing interest.

Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties

대장암-전이에는-dickkopf-2가-paneth-세포-특성을-가진-암세포를-생성하는-것이-필요하다


대장암 전이에는 Dickkopf-2가 Paneth 세포 특성을 가진 암세포를 생성하는 것이 필요하다


title_rewrite

대장암 전이에서 Paneth 세포 특성을 가진 암세포의 역할